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Клинические исследования в Украине

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Описание
Краткое названиеStudy of Radiation Exposure in Chernobyl Clean-up Workers With Leukemia, Multiple Myeloma, or Myelodysplasia
Полное названиеScientific Protocol for the Study of Leukemia and Other Hematologic Diseases Among Clean-up Workers in Ukraine Following the Chernobyl Accident
СпонсорNational Cancer Institute (NCI)
NIH
ИсточникNational Cancer Institute (NCI)
Под контролемUnspecified
Краткое описаниеRATIONALE: Studying the amount of radiation that patients were exposed to during the
clean-up following the Chernobyl nuclear accident may help doctors learn more about the
risks of developing leukemia, multiple myeloma, and myelodysplasia.

PURPOSE: This clinical trial is studying the effect of radiation exposure on patients with
leukemia, multiple myeloma, or myelodysplasia who were clean-up workers after the Chernobyl
nuclear power plant accident.
СостояниеИдет набор
Дата началаJuly 1996
ФазаN/A
Подробное описаниеOBJECTIVES:

Primary

- To test the hypothesis that there is a dose-related increase in risk of leukemia in the
liquidators involved in the cleanup work after the Chernobyl Nuclear Power Plant
accident in northern Ukraine in 1986.

- To test the hypothesis that the magnitude of any observed risk per unit dose in these
participants is less than that seen in the atomic bomb survivors, who were exposed to
essentially instantaneous radiation.

Secondary

- To investigate the nature of dose-response relationship in these participants.

- To identify modifiers of risk (e.g., time since exposure and age at exposure) in these
participants.

- To test the hypothesis that there is a dose-related increase in risk of multiple
myeloma in these participants.

- To test the hypothesis that there is a dose-related increase in risk of myelodysplasia
in these participants.

OUTLINE: Study participants undergo an interview and complete a questionnaire to provide
information on personal and family medical histories and occupational exposure to radiation.
Participants who are deceased are evaluated via interviews with spouses or other close
relatives to obtain medical histories as well as names of co-workers at Chernobyl. Dose
estimates of radiation exposure due to the Chernobyl accident or to medical sources of
radiation (i.e., CT scans or radiopharmaceuticals) are made during the dosimetry portion of
the interview.
Вид исследованияN/A
Набор0
КритерииDISEASE CHARACTERISTICS:

- Diagnosis of leukemia, multiple myeloma, or myelodysplasia based on retrospective
review of cohort records linked to the Ukranian Cancer Registry AND meets 1 of the
following criteria:

- Member of a cohort of approximately 100,000 Ukranian liquidators involved as
clean-up workers after the nuclear accident at Chernobyl Nuclear Power Plant in
northern Ukraine in 1986 AND meets the following criteria:

- In first year of service as a liquidator between the years 1986-1990

- Resident (when first registered in the Chernobyl State Registry) of Kiev
City or in one of five oblasts (i.e., major civil divisions) that comprise
the study area, including Cherkasy, Dnipropetrovsk, Chenihiv, Kiev, and
Kharkiv

- Under 60 years old at the time of employment at Chernobyl

- Not necessarily alive at selection

- Matched control patient

- Received mean bone marrow doses of approximately 80-100 milligray at low to moderate
dose rates

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified
ПолBoth
Минимальный возраст18 Years
Максимальный возрастN/A
УсловиеLeukemia
Применяемое лечение
Otherquestionnaire administration
Контакты и расположение
Kiev , 254050Research Centre for Radiation Medicine
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